{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001528115","name":"Annexon, Inc.","summary":"Annexon, Inc. is a biopharmaceutical company developing targeted immunotherapies for complement-mediated neuroinflammatory diseases affecting nearly 10 million people worldwide. Its pipeline includes tanruprubart (anti-C1q antibody for Guillain-Barré Syndrome), vonaprument (intravitreal C1q inhibitor for geographic atrophy/dry AMD), ANX1502 (oral small molecule C1s inhibitor for autoimmune conditions), and ANX009 (subcutaneous C1q-blocking Fab for lupus nephritis). The company targets the classical complement pathway by blocking C1q, the initiating molecule, across autoimmune, neurodegeneration, and ophthalmology therapeutic areas.","people":[],"products":[{"name":"Tanruprubart","type":"platform","description":"Investigational anti-C1q targeted immunotherapy delivered as a single infusion for Guillain-Barré Syndrome; granted FDA Fast Track and orphan drug designation and EMA orphan designation."},{"name":"Vonaprument","type":"platform","description":"Investigational intravitreal C1q inhibitor for dry AMD with geographic atrophy; first GA candidate to receive EMA PRIME designation; Phase 3 ARCHER II ongoing."},{"name":"ANX1502","type":"platform","description":"Novel oral small molecule inhibiting activated C1s for autoimmune conditions including cold agglutinin disease; Phase 1 completed, POC study ongoing."},{"name":"ANX009","type":"platform","description":"C1q-blocking Fab formulated for subcutaneous delivery targeting lupus nephritis; completed Phase 1b signal-finding trial showing target engagement and complement inhibition."}],"partnerships":[],"affiliations":[],"origin":{"leaf":"157ed2d4c3f9341e2ef1a3a0906e92578f50907969233d7788f6e0245a21e4d2","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"7dc074be6e604985da2d7c8a2205bab08f141d4756ecea22468c002349037e91","parent":"05fea8c3ae69f0c3b5e80905af33c07ea914eb7f489fe5a10c14c2f24c84b77a","source":"0001193125-26-131782","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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