{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001768224","name":"Arcturus Therapeutics Holdings Inc.","summary":"Arcturus Therapeutics is an mRNA medicines company focused on rare disease therapeutics and vaccines. It developed KOSTAIVE, the world's first approved self-amplifying mRNA (sa-mRNA) vaccine against COVID-19, approved in Japan, the EU, and UK. Its pipeline includes ARCT-032 for cystic fibrosis and ARCT-810 for OTC deficiency, leveraging its proprietary LUNAR lipid nanoparticle delivery and STARR sa-mRNA platforms.","people":[],"products":[{"name":"KOSTAIVE (ARCT-154)","type":"platform","description":"World's first approved sa-mRNA COVID-19 vaccine, approved in Japan, EU, and UK; commercialized in Japan starting October 2024."},{"name":"ARCT-032 (LUNAR-CF)","type":"platform","description":"Inhaled mRNA therapeutic candidate for cystic fibrosis delivering codon-optimized CFTR mRNA to airway epithelial cells."},{"name":"ARCT-810","type":"platform","description":"RNA therapeutic candidate in Phase 2 for ornithine transcarbamylase (OTC) deficiency, a rare liver disease."},{"name":"LUNAR","type":"platform","description":"Proprietary lipid nanoparticle delivery system using biodegradable synthetic and natural lipids to deliver nucleic acid medicines to target tissues."},{"name":"STARR","type":"platform","description":"Proprietary self-amplifying mRNA technology platform designed to induce robust, longer-lasting immune responses at lower doses than conventional mRNA vaccines."},{"name":"ARCT-2301","type":"platform","description":"Variant-specific sa-mRNA COVID-19 vaccine version developed under the KOSTAIVE brand."},{"name":"ARCT-2303","type":"platform","description":"Variant-specific sa-mRNA COVID-19 vaccine version developed under the KOSTAIVE brand."}],"partnerships":[{"partner_name":"CSL Seqirus (CSL Limited)","partnership_type":"development","description":"Partnership for development and commercialization of mRNA vaccines for COVID-19, influenza, and three other infectious diseases.","start_date":null},{"partner_name":"Meiji Seika Pharma, Ltd.","partnership_type":"strategic","description":"CSL Seqirus's exclusive partner in Japan responsible for commercial sales of KOSTAIVE starting October 2024.","start_date":null},{"partner_name":"Cystic Fibrosis Foundation (CFF)","partnership_type":"development","description":"CFF partnered with Arcturus to support development of ARCT-032 for cystic fibrosis.","start_date":null},{"partner_name":"Biomedical Advanced Research and Development Authority (BARDA)","partnership_type":"development","description":"BARDA funded a Phase 1 trial of Arcturus's sa-mRNA vaccine candidate against pandemic avian influenza.","start_date":null}],"affiliations":[],"origin":{"leaf":"b4f32a0ff9f06f4bd1d50cf77e65d232c6a6680507a03eaafd7dc9f002168aab","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"8fa1e3a389eb9eac136e4bc128e4d9847121e94d745cc8787e8e088b2fe2a4ef","parent":"1b1996044cb6a93fb607d3e704c82eb089ba9d893bc9fdc0a588836dc0f039f2","source":"0001193125-26-088391","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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