{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001655759","name":"ARVINAS, INC.","summary":"Arvinas, Inc. is a clinical-stage biotechnology company pioneering PROTAC (PROteolysis TArgeting Chimera) protein degradation therapeutics. Using its proprietary PROTAC Discovery Engine, Arvinas develops small molecule degraders that harness the body's natural protein disposal system to eliminate disease-causing proteins. Its pipeline includes vepdegestrant (breast cancer, NDA accepted by FDA with PDUFA date June 5, 2026), ARV-102 (Parkinson's disease/PSP), ARV-806 (KRAS-G12D cancers), ARV-393 (non-Hodgkin lymphoma), and ARV-027 (neuromuscular disease).","people":[],"products":[{"name":"vepdegestrant","type":"platform","description":"PROTAC degrader targeting estrogen receptor for ER+/HER2- advanced or metastatic breast cancer; NDA accepted by FDA with PDUFA date June 5, 2026."},{"name":"ARV-102","type":"platform","description":"PROTAC degrader targeting LRRK2 protein for neurodegenerative diseases including Parkinson's disease and progressive supranuclear palsy."},{"name":"ARV-806","type":"platform","description":"PROTAC degrader targeting KRAS-G12D protein for cancers including pancreatic, colorectal, and non-small cell lung cancer."},{"name":"ARV-393","type":"platform","description":"PROTAC degrader targeting BCL6 protein for relapsed/refractory non-Hodgkin lymphoma."},{"name":"ARV-027","type":"platform","description":"PROTAC degrader targeting polyglutamine-expanded androgen receptor in skeletal muscle."},{"name":"ARV-6723","type":"platform","description":"Preclinical PROTAC degrader targeting HPK1 (hematopoietic progenitor kinase 1)."},{"name":"PROTAC Discovery Engine","type":"platform","description":"Proprietary interlocking suite of tools including ANGLE, LEAP, PROTACify, PIVOT, E3KnowledgeBase, and proteomics capabilities for PROTAC drug discovery."}],"partnerships":[{"partner_name":"Pfizer, Inc.","partnership_type":"development","description":"Early-stage collaboration on PROTAC protein degrader programs; specific terms not disclosed.","start_date":null},{"partner_name":"Genentech, Inc. and F. 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