{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001674416","name":"CRISPR Therapeutics AG","summary":"CRISPR Therapeutics AG is a biopharmaceutical company focused on developing CRISPR/Cas9-based gene editing therapeutics. Its lead product, CASGEVY (exagamglogene autotemcel), received the world's first approval of a CRISPR-based therapy in 2023 for sickle cell disease and transfusion-dependent beta thalassemia, developed in collaboration with Vertex Pharmaceuticals. The company also pursues in vivo editing, allogeneic CAR T cell therapies for autoimmune and oncology indications, and regenerative medicine programs.","people":[],"products":[{"name":"CASGEVY (exagamglogene autotemcel, exa-cel)","type":"platform","description":"First approved CRISPR-based therapy for sickle cell disease and transfusion-dependent beta thalassemia; approved in the US and other countries in 2023."},{"name":"CTX112","type":"platform","description":"Allogeneic CAR T cell therapy candidate in development."},{"name":"CTX211","type":"platform","description":"Allogeneic CAR T cell therapy candidate in development."},{"name":"CTX213","type":"platform","description":"Allogeneic CAR T cell therapy candidate in clinical development."},{"name":"CTX310","type":"platform","description":"In vivo gene editing program candidate in development."},{"name":"CTX321","type":"platform","description":"In vivo gene editing program candidate in clinical development."},{"name":"CTX340","type":"platform","description":"Gene editing program candidate in development."},{"name":"CTX460","type":"platform","description":"Gene editing program candidate in development."},{"name":"CTX611","type":"platform","description":"Gene editing program candidate in clinical development."},{"name":"zugocabtagene geleucel","type":"platform","description":"CAR T cell therapy candidate in clinical development."},{"name":"SyNTase","type":"platform","description":"Proprietary technology platform developed by CRISPR Therapeutics, details limited in excerpt."}],"partnerships":[{"partner_name":"Vertex Pharmaceuticals Incorporated","partnership_type":"development","description":"Lead collaboration on CASGEVY program; Vertex is the manufacturer and exclusive license holder of CASGEVY. Also collaborating on targeted conditioning and in vivo hematopoietic stem cell editing.","start_date":null}],"affiliations":[],"origin":{"leaf":"c0facf1231288398ddfc10d827cc2348fce47b41b37c6e0c79213fd515bf6610","parent":"53c1af03709b48241eeb9dc002fdad009b1cc205a53f99b85ec795110dda840f","timestamp":"2026-08-19T05:27:10.436Z","source":"0001193125-26-048957","chain":"SEC.gov PEM > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Hash this response content + parent + timestamp to reproduce the leaf hash","keep_alive":"To continue the chain, include this leaf as your parent when you cite this data"},"_skill":{"_provenance":{"status":"This record carries an origin chain (see origin.leaf) traceable to an SEC-signed source. 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