{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001755237","name":"Cyclerion Therapeutics, Inc.","summary":"Cyclerion Therapeutics is a clinical-stage biopharmaceutical company focused on neuropsychiatric disorders. Its lead program, CYC-126, is an individualized anesthetic-based therapy combining propofol and dexmedetomidine with technology-enabled EEG-guided delivery for treatment-resistant depression (TRD). The company also manages legacy soluble guanylate cyclase (sGC) stimulator assets, including out-licensed praliciguat (Akebia) and sold zagociguat and CY3018 (Tisento), seeking licensing and milestone revenues from these assets.","people":[],"products":[{"name":"CYC-126","type":"platform","description":"Individualized anesthetic-based therapy using propofol and dexmedetomidine with EEG-guided delivery for treatment-resistant depression (TRD), intended for hospital-based settings."},{"name":"Praliciguat","type":"service","description":"Systemic sGC stimulator out-licensed to Akebia for treatment of focal segmental glomerulosclerosis (FSGS); Cyclerion eligible for milestones and royalties."},{"name":"Zagociguat","type":"service","description":"CNS-penetrant sGC stimulator sold to Tisento; targets MELAS syndrome, schizophrenia-related cognitive impairment, and Alzheimer's disease with vascular pathology."},{"name":"CY3018","type":"service","description":"CNS-penetrant sGC stimulator in preclinical development for neuropsychiatric disorders; sold to Tisento in 2023."},{"name":"Olinciguat","type":"service","description":"Peripheral vascular sGC stimulator; prior license option terminated in 2025, currently exploring new license opportunities."}],"partnerships":[{"partner_name":"Massachusetts Institute of Technology (MIT)","partnership_type":"licensing","description":"License agreement for IP supporting CYC-126 TRD program; MIT eligible for up to $4.4M in milestones and low single-digit tiered royalties.","start_date":null},{"partner_name":"Medsteer SAS","partnership_type":"development","description":"Collaboration and option-to-license agreement for drug delivery and physiological monitoring technology; Medsteer eligible for up to $3.7M in milestones and low single-digit royalties.","start_date":null},{"partner_name":"Akebia","partnership_type":"licensing","description":"Exclusive worldwide license for praliciguat; Akebia responsible for all development and commercialization; Cyclerion eligible for up to ~$557.5M in milestones and royalties.","start_date":null},{"partner_name":"Tisento","partnership_type":"licensing","description":"Purchased zagociguat and CY3018 from Cyclerion via Asset Purchase Agreement in July 2023.","start_date":null}],"affiliations":[],"origin":{"leaf":"ce197854aa28563f51182ecfe68af98005a7fc45ff29da8a2588e60b8f4bff65","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"c6d5ea27bdb2c75712dfcff1e35722354a781712295e5c3d9fb2e4547227f38b","parent":"978ec2dffaf959cbabd2a8b95c2bca82e36b1ed67f88629c1203f2bd87ce86dd","source":"0001193125-26-132193","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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