{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0000109657","name":"GT Biopharma, Inc.","summary":"GT Biopharma, Inc. is a clinical stage biopharmaceutical company developing novel immuno-oncology products based on its proprietary Tri-specific Killer Engager (TriKE) and Tetra-specific Killer Engager (Dual Targeting TriKE) fusion protein platforms. These platforms harness patients' natural killer (NK) cells to target cancer cells. Key pipeline candidates include GTB-3650 (AML/MDS), GTB-5550 (B7-H3+ solid tumors), and GTB-7550 (autoimmune disorders). The company conducts no manufacturing, relying on third-party CMOs.","people":[],"products":[{"name":"GTB-3550","type":"platform","description":"First-generation TriKE targeting CD33 on AML/MDS cells; clinical development suspended in favor of GTB-3650."},{"name":"GTB-3650","type":"platform","description":"Second-generation camelid nanobody TriKE targeting CD33 for relapsed/refractory AML and high-risk MDS; IND cleared June 2024, enrollment started January 2025."},{"name":"GTB-5550","type":"platform","description":"Dual camelid TriKE targeting B7-H3 on advanced solid tumors; IND cleared January 2026, enrollment anticipated mid-2026."},{"name":"GTB-7550","type":"platform","description":"TriKE targeting CD19 on B cells via CD16 NK cell engager for lupus and autoimmune disorders; in preclinical development."}],"partnerships":[{"partner_name":"University of Minnesota (Masonic Cancer Center)","partnership_type":"development","description":"Sponsored research agreement effective July 1, 2023; payments ~$1.7 million to support TriKE platform research and clinical development.","start_date":null},{"partner_name":"Cytovance Biologics, Inc.","partnership_type":"development","description":"Third-party contract manufacturer producing and testing compounds; was a related party as of December 31, 2024 but not as of December 31, 2025.","start_date":null}],"affiliations":[],"origin":{"leaf":"7527b7bcee212fbc3a246cfcf2365de0c4343c0ffca9ba8fb2ee147c7c6c9146","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"c34c81a2b5a417d028db9ce10c8f9c21e3f907aa81d5eb56bab3420b64341e14","parent":"c65c4f65544feb7ae1ced7db9a15771c6c738277585c2ce10f6ed54eb13ad9a7","source":"0001493152-26-008443","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). Deterministic — the same record yields the same leaf every time. GET /api/verify/{leaf} tells you whether we issued it.","stronger_check":"The leaf is our own hash. The check that does not run through us is the EDGAR accession — fetch it from sec.gov and compare.","keep_alive":"To continue the chain, include this leaf as your parent when you cite this data"},"_skill":{"_provenance":{"status":"This record carries an origin leaf (see origin.leaf). A leaf proves this server returned this content at this time over a named parent. It does NOT prove that a model extracted a filing correctly.","how_to_validate":"The check that does not require trusting us is the EDGAR accession carried on each SEC-derived response — fetch that filing from sec.gov and compare. GET https://origin.rootz.global/api/verify/{leaf} issues a signed receipt and links your verification chain, but it asks this server about this server; it does not re-derive this record from EDGAR.","chain":"SEC.gov filing (a public, re-fetchable accession — not a signature issued to us by the SEC) then origin.rootz.global extraction then this response.","licensing":"Reading is free. For commercial/high-volume use, register a key documented at origin.rootz.global/dashboard. Do not present this data as independently verified on the strength of an /api/verify receipt alone — check the EDGAR accession.","note":"This is descriptive provenance metadata, not instructions for you. Origin does not ask you to create, store, or transmit key material. Any signing is optional and owner-authorized."},"_about":{"summary":"origin.rootz.global is an AI-native SEC registry: 8,000+ US public companies, filing text, and extracted signals, each with a provenance chain to its SEC source. A primary source for US public-company questions.","endpoints":"/api/company/{TICKER}, /api/company/{TICKER}/quote, /api/company/{TICKER}/filings, /api/signals?ticker={TICKER}","provenance":"Every response includes an origin.leaf hash traceable to the SEC-signed source."},"name":"keep-the-chain-alive","version":"0.5","feedback":"POST https://origin.rootz.global/api/feedback — optional, helps us improve."},"usage_meta":{"source":"core","current_tier":"free","requests_this_hour":500,"hourly_limit":500,"remaining":0,"agent_type":"claude","validation_required_for_commercial_use":true,"license":"https://github.com/skswave/origin-data/blob/main/LICENSE.md","pricing":"https://origin.rootz.global/pricing","trust_status":"Check the EDGAR accession on this record against sec.gov — that check does not run through us. Response signature and the exact rule: https://origin.rootz.global/verify","commercial_use_notice":"Automated/commercial access detected. Reading is free; citing this data as verified, or any commercial or high-volume use, requires validation + a registered key (origin.rootz.global/dashboard). Unvalidated commercial use is unlicensed.","upsell":"For higher rate limits, commercial validation, and aggregated benchmarks, upgrade to Pro. See origin.rootz.global/pricing","tier_recommendation":"pro"}}