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The company also holds TBS-2025, a VISTA-inhibiting monoclonal antibody acquired via Kineta for AML treatment, and a Delta Opioid Receptor ADC technology targeting myeloid-derived suppressor cells.","people":[],"products":[{"name":"IFx-2.0","type":"platform","description":"Innate immune agonist pDNA injected intratumorally to make tumor cells resemble bacteria, overcoming primary resistance to checkpoint inhibitors; in Phase 3 trial for Merkel cell carcinoma."},{"name":"TBS-2025","type":"platform","description":"Novel VISTA-inhibiting monoclonal antibody (formerly KVA1213) acquired from Kineta, planned for Phase 1b/2 trial in relapsed/refractory NPM1-mutated AML."},{"name":"Delta Opioid Receptor ADC","type":"platform","description":"First-in-class bi-functional, bi-specific antibody-drug conjugate targeting DOR on MDSCs to prevent T cell exhaustion and acquired resistance to checkpoint inhibitors."}],"partnerships":[{"partner_name":"FDA (Oncology Center of Excellence)","partnership_type":"development","description":"Special Protocol Assessment agreement for Phase 3 trial of IFx-2.0 as adjunctive therapy to pembrolizumab in Merkel cell carcinoma using accelerated approval pathway.","start_date":null}],"affiliations":[],"origin":{"leaf":"08a995eb53f2a78b35d16238719053bee817117ef40a9feff41632c1ae2c4e37","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"08d769577df7432816ce687f49103b51c9bb018cae9e51b20eca8700455dccd5","parent":"2117a01fe85bba8624427edb3611705c26adc67ea85786b0c9e404098e48836a","source":"0001193125-26-134950","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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