{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001506184","name":"IMMUTEP Ltd","summary":"IMMUTEP Ltd is an Australian development-stage biopharmaceutical company focused on immunotherapeutic products for cancer and autoimmune diseases, all related to LAG-3 (lymphocyte activation gene 3). Its five programs include eftilagimod alfa (efti/IMP321), IMP701 (ieramilimab), IMP731, IMP761, and an early-stage anti-LAG-3 small molecule. Efti, its most advanced candidate, is being evaluated in Phase II and Phase III trials in combination with pembrolizumab (MSD) and avelumab (Merck KGaA/Pfizer). The company also sells LAG-3 research reagents.","people":[],"products":[{"name":"eftilagimod alfa (efti/IMP321)","type":"platform","description":"Recombinant LAG-3 protein immune activator used in combination with chemotherapy or immunotherapy for cancer treatment."},{"name":"IMP701 (ieramilimab/LAG525)","type":"platform","description":"Antagonist antibody stimulating T cell proliferation in cancer patients, licensed to Novartis via CoStim acquisition."},{"name":"IMP731","type":"platform","description":"Depleting antibody targeting T cells involved in autoimmunity; previously licensed and transferred back to Immutep."},{"name":"IMP761","type":"platform","description":"Clinical-stage agonist antibody of LAG-3 developed for autoimmune disease applications."},{"name":"Anti-LAG-3 small molecule program","type":"platform","description":"Early-stage research program targeting LAG-3 via small molecule approach."},{"name":"LAG-3 research reagents","type":"service","description":"Commercial research reagents related to LAG-3, generating modest income for the company."}],"partnerships":[{"partner_name":"Merck & Co., Inc. (MSD)","partnership_type":"development","description":"Three clinical trial collaboration and supply agreements to evaluate efti combined with pembrolizumab in Phase II and Phase III trials.","start_date":null},{"partner_name":"Merck KGaA","partnership_type":"development","description":"Clinical trial collaboration and supply agreements to evaluate efti combined with avelumab in Phase I trials.","start_date":null},{"partner_name":"Pfizer","partnership_type":"development","description":"Clinical trial collaboration and supply agreements to evaluate efti combined with avelumab (PD-L1 antibody) in Phase I trials.","start_date":null},{"partner_name":"EOC Pharma","partnership_type":"licensing","description":"Licensee conducting development and manufacturing of efti in China.","start_date":null},{"partner_name":"Novartis (via CoStim Pharmaceuticals)","partnership_type":"licensing","description":"IMP701 fully licensed to CoStim, subsequently acquired by Novartis, which is solely responsible for development and manufacturing.","start_date":null}],"affiliations":[],"origin":{"leaf":"a1bd92c473a8a2985f4595075d8bc34b57bf708e1e182eeff77339f435a568cc","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"e88bb0981e596670e8bf623bdf44a1abf59a03337461f39bb32086bc8f7f33a1","parent":"01ed5dab11767b07fb32f9f5a1dc674a845d8280062a11c32db3e35d6b840192","source":"0001193125-25-249346","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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