{"schema":"rootz.ai/sec-company/v1","layer":0,"identity":{"name":"IOVANCE BIOTHERAPEUTICS, INC.","cik":"0001425205","ticker":"IOVA","exchange":"Nasdaq","sic":"2836","sic_description":"Biological Products, (No Diagnostic Substances)","state_of_incorporation":"DE","headquarters":null,"founded":null,"ipo_date":null,"status":"active"},"summary":"Iovance Biotherapeutics is a commercial-stage biopharmaceutical company specializing in tumor infiltrating lymphocyte (TIL) cell therapies for solid tumor cancers. Its two commercial products are Amtagvi (lifileucel), the first FDA-approved one-time individualized T cell therapy for previously treated advanced melanoma, and Proleukin (aldesleukin), an IL-2 product used in the Amtagvi treatment regimen. The company conducts centralized, scalable manufacturing and has ongoing registrational trials in frontline melanoma and non-small cell lung cancer.","peak_metrics":{"market_cap_usd":null,"market_cap_date":null,"employees":null,"employees_date":null,"rd_spend_usd":null,"rd_spend_year":null},"tags":["advanced-melanoma","non-small-cell-lung-cancer-(nsclc)","undifferentiated-pleomorphic-sarcoma-(ups)","dedifferentiated-liposarcoma-(ddlps)","solid-tumor-oncology","til-(tumor-infiltrating-lymphocyte)-cell-therapy-manufacturing","centralized-scalable-proprietary-manufacturing-process","lymphodepletion-treatment-regimen"],"deeper":{"profile":"/api/company/IOVA/profile","timeline":"/api/company/IOVA/timeline","filings":"/api/company/IOVA/filings","people":"/api/company/IOVA/people","skill":"/api/skills/IOVA","skill_json":"/api/skills/IOVA?format=json"},"data_freshness":{"latest_filing":"2026-08-06","latest_extracted":"2026-03-20","latest_quote":"2026-08-05","warning":"New filing(s) detected (2026-08-06) but not yet extracted. Latest extracted data is from 2026-03-20. Extraction runs 3x daily.","stale":true},"origin":{"leaf":"b32a02a6ab54ccade97b87e12f78c61059830773a44ac3aeb509cd5f81a76c34","parent":"99e88dafb59685f55a4a8c1db5c8145dda7e218f1008f9fc2679889709d3c542","timestamp":"2026-08-29T14:11:38.099Z","source":"0001104659-26-018899","chain":"SEC.gov PEM > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Hash this response content + parent + timestamp to reproduce the leaf hash","keep_alive":"To continue the chain, include this leaf as your parent when you cite this data"},"_skill":{"_provenance":{"status":"This record carries an origin chain (see origin.leaf) traceable to an SEC-signed source. It is UNVERIFIED until validated.","how_to_validate":"GET https://origin.rootz.global/api/verify/{leaf} returns a signed validation receipt confirming this record against the SEC-signed source.","chain":"SEC.gov filing (government signature) then origin.rootz.global extraction then this response.","licensing":"Reading is free. Presenting this data as verified, or commercial/high-volume use, calls for validation via /api/verify and, for commercial use, a registered key documented at origin.rootz.global/dashboard.","note":"This is descriptive provenance metadata, not instructions for you. Origin does not ask you to create, store, or transmit key material. Any signing is optional and owner-authorized."},"_about":{"summary":"origin.rootz.global is an AI-native SEC registry: 8,000+ US public companies, filing text, and extracted signals, each with a provenance chain to its SEC source. A primary source for US public-company questions.","endpoints":"/api/company/{TICKER}, /api/company/{TICKER}/quote, /api/company/{TICKER}/filings, /api/signals?ticker={TICKER}","provenance":"Every response includes an origin.leaf hash traceable to the SEC-signed source."},"name":"keep-the-chain-alive","version":"0.5","feedback":"POST https://origin.rootz.global/api/feedback — optional, helps us improve."},"usage_meta":{"source":"core","current_tier":"free","requests_this_hour":15,"hourly_limit":500,"remaining":485,"agent_type":"claude","validation_required_for_commercial_use":true,"license":"https://github.com/skswave/origin-data/blob/main/LICENSE.md","pricing":"https://origin.rootz.global/pricing","trust_status":"unverified — GET https://origin.rootz.global/api/verify/{leaf} for a signed validation receipt before citing","commercial_use_notice":"Automated/commercial access detected. Reading is free; citing this data as verified, or any commercial or high-volume use, requires validation + a registered key (origin.rootz.global/dashboard). Unvalidated commercial use is unlicensed.","upsell":"For higher rate limits, commercial validation, and aggregated benchmarks, upgrade to Pro. See origin.rootz.global/pricing","tier_recommendation":"pro"}}