{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001446847","name":"IRONWOOD PHARMACEUTICALS INC","summary":"Ironwood Pharmaceuticals is a biotechnology company developing and commercializing therapies for gastrointestinal and rare diseases. Its commercial product, LINZESS (linaclotide), a GC-C agonist, is FDA-approved for IBS-C, CIC, and FC in adults and pediatric patients. Ironwood is also advancing apraglutide, a GLP-2 analog, for short bowel syndrome with intestinal failure (SBS-IF), with a confirmatory Phase III trial (STARS-2) planned for 2026.","people":[],"products":[{"name":"LINZESS (linaclotide)","type":"service","description":"FDA-approved GC-C agonist for IBS-C, CIC in adults, and FC in pediatric patients ages 6-17; also marketed globally as CONSTELLA."},{"name":"Apraglutide","type":"service","description":"Next-generation synthetic GLP-2 analog in Phase III development for short bowel syndrome with intestinal failure dependent on parenteral support."},{"name":"IW-3300","type":"service","description":"GC-C agonist previously in Phase II development for visceral pain conditions including interstitial cystitis/bladder pain syndrome; development ceased April 2025."}],"partnerships":[{"partner_name":"AbbVie Inc.","partnership_type":"strategic","description":"Co-commercializes LINZESS in the U.S. and holds rights to develop and commercialize linaclotide in all countries except China, Hong Kong, Macau, and Japan.","start_date":null},{"partner_name":"AstraZeneca AB","partnership_type":"licensing","description":"Has rights to develop, manufacture, and commercialize linaclotide in China, including Hong Kong and Macau.","start_date":null},{"partner_name":"Astellas Pharma Inc.","partnership_type":"licensing","description":"Has rights to develop, manufacture, and commercialize linaclotide in Japan; began commercializing LINZESS in Japan in 2017.","start_date":null}],"affiliations":[],"origin":{"leaf":"be1becc9577f1949179dd971b832d262eaa12d4950bf9b805c774b5d336831b7","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"694647a9710243c4902d4ddeb005db10e8da8fecf850e2a9343674639005c35d","parent":"266ea1be666d7b68548e6c5bb0220e70587bb595922c8ec4ced01110791bb310","source":"0001104659-26-020489","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). Deterministic — the same record yields the same leaf every time. GET /api/verify/{leaf} tells you whether we issued it.","stronger_check":"The leaf is our own hash. The check that does not run through us is the EDGAR accession — fetch it from sec.gov and compare.","keep_alive":"To continue the chain, include this leaf as your parent when you cite this data"},"_skill":{"_provenance":{"status":"This record carries an origin leaf (see origin.leaf). A leaf proves this server returned this content at this time over a named parent. It does NOT prove that a model extracted a filing correctly.","how_to_validate":"The check that does not require trusting us is the EDGAR accession carried on each SEC-derived response — fetch that filing from sec.gov and compare. GET https://origin.rootz.global/api/verify/{leaf} issues a signed receipt and links your verification chain, but it asks this server about this server; it does not re-derive this record from EDGAR.","chain":"SEC.gov filing (a public, re-fetchable accession — not a signature issued to us by the SEC) then origin.rootz.global extraction then this response.","licensing":"Reading is free. For commercial/high-volume use, register a key documented at origin.rootz.global/dashboard. Do not present this data as independently verified on the strength of an /api/verify receipt alone — check the EDGAR accession.","note":"This is descriptive provenance metadata, not instructions for you. Origin does not ask you to create, store, or transmit key material. Any signing is optional and owner-authorized."},"_about":{"summary":"origin.rootz.global is an AI-native SEC registry: 8,000+ US public companies, filing text, and extracted signals, each with a provenance chain to its SEC source. A primary source for US public-company questions.","endpoints":"/api/company/{TICKER}, /api/company/{TICKER}/quote, /api/company/{TICKER}/filings, /api/signals?ticker={TICKER}","provenance":"Every response includes an origin.leaf hash traceable to the SEC-signed source."},"name":"keep-the-chain-alive","version":"0.5","feedback":"POST https://origin.rootz.global/api/feedback — optional, helps us improve."},"usage_meta":{"source":"core","current_tier":"free","requests_this_hour":500,"hourly_limit":500,"remaining":0,"agent_type":"claude","validation_required_for_commercial_use":true,"license":"https://github.com/skswave/origin-data/blob/main/LICENSE.md","pricing":"https://origin.rootz.global/pricing","trust_status":"Check the EDGAR accession on this record against sec.gov — that check does not run through us. Response signature and the exact rule: https://origin.rootz.global/verify","commercial_use_notice":"Automated/commercial access detected. Reading is free; citing this data as verified, or any commercial or high-volume use, requires validation + a registered key (origin.rootz.global/dashboard). Unvalidated commercial use is unlicensed.","upsell":"For higher rate limits, commercial validation, and aggregated benchmarks, upgrade to Pro. See origin.rootz.global/pricing","tier_recommendation":"pro"}}