{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001355790","name":"International Stem Cell CORP","summary":"International Stem Cell Corporation (ISCO) is a clinical-stage biotechnology company developing therapeutic products based on human parthenogenetic stem cells (hpSCs). Its lead program, ISC-hpNSC, uses neural stem cells for Parkinson's disease treatment, completing a Phase 1 trial in June 2021. ISCO also generates revenue (~$9.1M annually) from two commercial businesses: anti-aging products and research products, leveraging multi-decade human cell culture expertise.","people":[],"products":[{"name":"ISC-hpNSC","type":"service","description":"Human parthenogenetic stem cell-derived neural stem cells for treatment of Parkinson's disease and potentially other CNS disorders, administered via intracerebral transplantation."},{"name":"Anti-aging products","type":"hardware","description":"Revenue-generating commercial products based on human cell culture technology targeting anti-aging applications."},{"name":"Research products","type":"service","description":"Commercial research products derived from stem cell technology generating recurring revenue."}],"partnerships":[],"affiliations":[],"origin":{"leaf":"f8c435c7e277db408ab9df1c85a4bfd5eb8c738ebc06739af5760c02ab8950e8","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"7af3f205593cb6be9ee147ba1c29b30493fd77654bc47fa47af3331e16500294","parent":"fb6d562055639ea3aa835b3152fe6ac7c5bc6a37ca445988fdf3a1cf9b6b2116","source":"0001193125-26-131723","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). Deterministic — the same record yields the same leaf every time. GET /api/verify/{leaf} tells you whether we issued it.","stronger_check":"The leaf is our own hash. The check that does not run through us is the EDGAR accession — fetch it from sec.gov and compare.","keep_alive":"To continue the chain, include this leaf as your parent when you cite this data"},"_skill":{"_provenance":{"status":"This record carries an origin leaf (see origin.leaf). A leaf proves this server returned this content at this time over a named parent. It does NOT prove that a model extracted a filing correctly.","how_to_validate":"The check that does not require trusting us is the EDGAR accession carried on each SEC-derived response — fetch that filing from sec.gov and compare. GET https://origin.rootz.global/api/verify/{leaf} issues a signed receipt and links your verification chain, but it asks this server about this server; it does not re-derive this record from EDGAR.","chain":"SEC.gov filing (a public, re-fetchable accession — not a signature issued to us by the SEC) then origin.rootz.global extraction then this response.","licensing":"Reading is free. For commercial/high-volume use, register a key documented at origin.rootz.global/dashboard. Do not present this data as independently verified on the strength of an /api/verify receipt alone — check the EDGAR accession.","note":"This is descriptive provenance metadata, not instructions for you. Origin does not ask you to create, store, or transmit key material. Any signing is optional and owner-authorized."},"_about":{"summary":"origin.rootz.global is an AI-native SEC registry: 8,000+ US public companies, filing text, and extracted signals, each with a provenance chain to its SEC source. A primary source for US public-company questions.","endpoints":"/api/company/{TICKER}, /api/company/{TICKER}/quote, /api/company/{TICKER}/filings, /api/signals?ticker={TICKER}","provenance":"Every response includes an origin.leaf hash traceable to the SEC-signed source."},"name":"keep-the-chain-alive","version":"0.5","feedback":"POST https://origin.rootz.global/api/feedback — optional, helps us improve."},"usage_meta":{"source":"core","current_tier":"free","requests_this_hour":49,"hourly_limit":500,"remaining":451,"agent_type":"claude","validation_required_for_commercial_use":true,"license":"https://github.com/skswave/origin-data/blob/main/LICENSE.md","pricing":"https://origin.rootz.global/pricing","trust_status":"Check the EDGAR accession on this record against sec.gov — that check does not run through us. Response signature and the exact rule: https://origin.rootz.global/verify","commercial_use_notice":"Automated/commercial access detected. Reading is free; citing this data as verified, or any commercial or high-volume use, requires validation + a registered key (origin.rootz.global/dashboard). Unvalidated commercial use is unlicensed.","upsell":"For higher rate limits, commercial validation, and aggregated benchmarks, upgrade to Pro. See origin.rootz.global/pricing","tier_recommendation":"pro"}}