{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001335105","name":"LIXTE BIOTECHNOLOGY HOLDINGS, INC.","summary":"LIXTE Biotechnology Holdings, Inc. is a clinical-stage biopharmaceutical and proton cancer therapy company. Its primary asset is LB-100, a small molecule inhibitor of protein phosphatase 2A (PP2A) being tested in clinical trials for ovarian clear cell carcinoma, metastatic MSS colon cancer, and advanced soft tissue sarcoma. The company is also the majority shareholder of Liora Technologies Europe Ltd., which is developing the LiGHT System, an electronically controlled proton therapy system for treating tumors.","people":[],"products":[{"name":"LB-100","type":"platform","description":"Small molecule inhibitor of PP2A with FDA IND status, tested in clinical trials for ovarian clear cell carcinoma, metastatic MSS colon cancer, and advanced soft tissue sarcoma."},{"name":"LB-200","type":"platform","description":"Histone deacetylase inhibitor (HDACi) series designed by the company; not yet advanced to clinical stage and not actively pursued."},{"name":"LiGHT System","type":"hardware","description":"Linac for Image Guided Hadron Therapy; electronically controlled proton therapy system developed by majority-owned subsidiary Liora Technologies Europe Ltd."}],"partnerships":[{"partner_name":"Spanish Sarcoma Group (GEIS)","partnership_type":"development","description":"Collaboration Agreement for investigator-initiated Phase 1b/randomized Phase 2 clinical trial of LB-100 plus doxorubicin in advanced soft tissue sarcoma; Phase 2 portion subsequently cancelled via Amendment No. 1 in March 2025.","start_date":null},{"partner_name":"National Institute of Neurologic Disorders and Stroke (NINDS/NIH)","partnership_type":"development","description":"Cooperative Research and Development Agreement (CRADA) initiated in 2006 for LB-100 series research; terminated April 1, 2013.","start_date":null}],"affiliations":[],"origin":{"leaf":"89a8ea43049ff04063e73ad6d709e4738970ba552503b8774ccf3864a3433f41","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"35294d45ec430ed606c3e739755b15c2a69e0623b81e7960f05a05cd750f93ed","parent":"626a45376c351bd70aeb699acae320650fbd94b18362ef65bf90c6bf42a23e95","source":"0001493152-26-014052","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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