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The pipeline also includes NMRA-511 (V1aR antagonist for AD agitation), NMRA-898 (M4 PAM for schizophrenia), NMRA-215 (NLRP3 inhibitor for obesity), NMRA-GCase (Parkinson's disease), and NMRA-CK1 (ALS).","people":[],"products":[{"name":"Navacaprant (NMRA-140)","type":"platform","description":"Once-daily oral KOR antagonist in Phase 3 (KOASTAL program) for monotherapy treatment of major depressive disorder."},{"name":"NMRA-511","type":"platform","description":"Highly potent, selective V1aR antagonist in Phase 1b development for agitation associated with Alzheimer's disease dementia."},{"name":"NMRA-898","type":"platform","description":"M4 muscarinic receptor PAM with ~80-100 hour half-life in Phase 1 for schizophrenia treatment."},{"name":"NMRA-861","type":"platform","description":"M4 muscarinic receptor PAM, part of Neumora's M4 franchise licensed from Vanderbilt University."},{"name":"NMRA-215","type":"platform","description":"Brain-penetrant oral NLRP3 inhibitor in preclinical development targeting hypothalamic neuroinflammation for obesity treatment."},{"name":"NMRA-GCase","type":"platform","description":"Preclinical GCase activator program for Parkinson's disease, targeting lysosomal dysfunction associated with GBA1 mutations."},{"name":"NMRA-CK1","type":"platform","description":"Preclinical CK1 delta inhibitor targeting TDP-43 phosphorylation for treatment of ALS."}],"partnerships":[{"partner_name":"Amgen","partnership_type":"licensing","description":"Exclusive license of intellectual property rights related to NMRA-GCase and NMRA-CK1 programs.","start_date":null},{"partner_name":"Warren Center for Neuroscience Drug Discovery at Vanderbilt University","partnership_type":"licensing","description":"Exclusive license of intellectual property rights related to NMRA-861 and NMRA-898 M4 PAM programs.","start_date":null}],"affiliations":[],"origin":{"leaf":"70bb1c99982f679b2edbb7ccd75780140093e6acbaa69a6b7eb7c9568526c2d8","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"b6a073fe4907e014797102dd6cb8c51ed7091213c017a214b0d85950f382a1e4","parent":"2f32270b84c2f3298f30e8209b6398aebfa7cdb571d3dcc37914f2f5b966e0ab","source":"0001193125-26-130388","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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