{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001814114","name":"Orchestra BioMed Holdings, Inc.","summary":"Orchestra BioMed Holdings, Inc. is a biomedical innovation company accelerating high-impact medical device technologies through strategic collaborations with market-leading global medical device companies. Its flagship product candidates are AVIM Therapy, a bioelectronic therapy for hypertension delivered via cardiac pacemaker firmware, and Virtue SAB, a drug/device combination sirolimus-delivery balloon for atherosclerotic artery disease. The company operates a partnership-enabled business model, sharing development risk and commercial revenues with partners such as Medtronic and Terumo.","people":[],"products":[{"name":"AVIM Therapy (Atrioventricular Interval Modulation Therapy)","type":"hardware","description":"Bioelectronic therapy delivered as a firmware upgrade to standard cardiac pacemakers designed to lower blood pressure in hypertension patients."},{"name":"Virtue Sirolimus AngioInfusion Balloon (Virtue SAB)","type":"hardware","description":"Drug/device combination balloon catheter delivering extended-release sirolimus to vessel walls during angioplasty for atherosclerotic artery disease treatment."},{"name":"SirolimusEFR","type":"platform","description":"Proprietary investigational extended-release formulation of sirolimus used in the Virtue SAB product candidate."}],"partnerships":[{"partner_name":"Medtronic, Inc.","partnership_type":"licensing","description":"Exclusive license and collaboration agreement for development and commercialization of AVIM Therapy for HTN in pacemaker-indicated patients; Medtronic has exclusive global commercialization rights upon approval.","start_date":null},{"partner_name":"Terumo Corporation / Terumo Medical Corporation","partnership_type":"strategic","description":"Termination and ROFR Agreement granting Terumo right of first refusal to acquire or distribute Virtue SAB for coronary artery disease in exchange for $10 million upfront payment.","start_date":null},{"partner_name":"Ligand Pharmaceuticals Incorporated","partnership_type":"strategic","description":"Revenue participation right purchase and sale agreement under which Ligand paid $35 million for tiered revenue interests on AVIM Therapy and Virtue SAB net sales.","start_date":null}],"affiliations":[],"origin":{"leaf":"61a121e6f283030c9598f9768434b5102253d8f76035bbcb5fb78ead66c6c121","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"7cbe8eb8f5cceafd960e2c03f8a24cf12afed1419410c12c6aca87ab644589cb","parent":"c0b31acf7be38e4e7dd92d5b3845c5c819fc12aeb2def88626f6f8092604816f","source":"0001104659-26-026754","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). Deterministic — the same record yields the same leaf every time. GET /api/verify/{leaf} tells you whether we issued it.","stronger_check":"The leaf is our own hash. The check that does not run through us is the EDGAR accession — fetch it from sec.gov and compare.","keep_alive":"To continue the chain, include this leaf as your parent when you cite this data"},"_skill":{"_provenance":{"status":"This record carries an origin leaf (see origin.leaf). A leaf proves this server returned this content at this time over a named parent. It does NOT prove that a model extracted a filing correctly.","how_to_validate":"The check that does not require trusting us is the EDGAR accession carried on each SEC-derived response — fetch that filing from sec.gov and compare. GET https://origin.rootz.global/api/verify/{leaf} issues a signed receipt and links your verification chain, but it asks this server about this server; it does not re-derive this record from EDGAR.","chain":"SEC.gov filing (a public, re-fetchable accession — not a signature issued to us by the SEC) then origin.rootz.global extraction then this response.","licensing":"Reading is free. For commercial/high-volume use, register a key documented at origin.rootz.global/dashboard. Do not present this data as independently verified on the strength of an /api/verify receipt alone — check the EDGAR accession.","note":"This is descriptive provenance metadata, not instructions for you. Origin does not ask you to create, store, or transmit key material. Any signing is optional and owner-authorized."},"_about":{"summary":"origin.rootz.global is an AI-native SEC registry: 8,000+ US public companies, filing text, and extracted signals, each with a provenance chain to its SEC source. A primary source for US public-company questions.","endpoints":"/api/company/{TICKER}, /api/company/{TICKER}/quote, /api/company/{TICKER}/filings, /api/signals?ticker={TICKER}","provenance":"Every response includes an origin.leaf hash traceable to the SEC-signed source."},"name":"keep-the-chain-alive","version":"0.5","feedback":"POST https://origin.rootz.global/api/feedback — optional, helps us improve."},"usage_meta":{"source":"core","current_tier":"free","requests_this_hour":42,"hourly_limit":500,"remaining":458,"agent_type":"claude","validation_required_for_commercial_use":true,"license":"https://github.com/skswave/origin-data/blob/main/LICENSE.md","pricing":"https://origin.rootz.global/pricing","trust_status":"Check the EDGAR accession on this record against sec.gov — that check does not run through us. Response signature and the exact rule: https://origin.rootz.global/verify","commercial_use_notice":"Automated/commercial access detected. Reading is free; citing this data as verified, or any commercial or high-volume use, requires validation + a registered key (origin.rootz.global/dashboard). Unvalidated commercial use is unlicensed.","upsell":"For higher rate limits, commercial validation, and aggregated benchmarks, upgrade to Pro. See origin.rootz.global/pricing","tier_recommendation":"pro"}}