{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001377121","name":"Protagonist Therapeutics, Inc","summary":"Protagonist Therapeutics is an integrated drug discovery and development company focused on inflammation and immunology, hematology, and metabolic diseases. Its key products include Icotyde (icotrokinra), an oral IL-23R antagonist licensed to Johnson & Johnson for psoriasis, and rusfertide, an injectable hepcidin mimetic for polycythemia vera partnered with Takeda. The company also has early-stage programs in IL-17 antagonism (PN-881) and obesity (PN-477, PN-458), leveraging a proprietary peptide platform.","people":[],"products":[{"name":"Icotyde (icotrokinra)","type":"platform","description":"First-in-class oral peptide IL-23R antagonist for moderate-to-severe plaque psoriasis; NDA submitted to FDA and EMA in 2025 by JNJ."},{"name":"Rusfertide","type":"platform","description":"First-in-class injectable hepcidin mimetic for polycythemia vera; NDA submitted to FDA in December 2025 with Takeda."},{"name":"PN-881","type":"platform","description":"Potential best-in-class oral peptide IL-17 antagonist targeting IL-17 AA, AF, and FF dimers; Phase 1 initiated October 2025."},{"name":"PN-477","type":"platform","description":"Novel triple GLP-1, GIP and GCG receptor agonist peptide for obesity; available in oral and subcutaneous formulations; development candidate nominated June 2025."},{"name":"PN-458","type":"platform","description":"Novel dual GLP-1 and GIP receptor agonist peptide for obesity in oral and subcutaneous formulations; development candidate nominated December 2025."},{"name":"PN-8047","type":"platform","description":"Oral hepcidin functional mimetic small molecule for polycythemia vera; development candidate nominated December 2025; IND-enabling studies ongoing."}],"partnerships":[{"partner_name":"Janssen Biotech, Inc. (Johnson & Johnson)","partnership_type":"licensing","description":"License and collaboration agreement for Icotyde; JNJ responsible for Phase 2+ development and commercialization; Protagonist eligible for up to $630M in future milestones and royalties of 6%-10%.","start_date":null},{"partner_name":"Takeda Pharmaceuticals, Inc.","partnership_type":"development","description":"Worldwide license and collaboration agreement for rusfertide; 50/50 U.S. profit/loss sharing with opt-out option; tiered ex-U.S. royalties 10%-17%; up to $975M in milestones.","start_date":null}],"affiliations":[],"origin":{"leaf":"ba233485a12cbf9832a37f5f73603f5f502b72d1efda6528494d08d6f1916814","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"3112fa07e77905c525eeff2f8d8f6ca6bc0db6d2dc07abedaeb30c2b4eb47da5","parent":"fcc197aef26e298a03a117015c856277a22cb7a9a2f1c52b683e25c8ec002988","source":"0001104659-26-019696","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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