{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001034842","name":"RIGEL PHARMACEUTICALS INC","summary":"Rigel Pharmaceuticals is a biotechnology company focused on developing and commercializing novel therapies for hematologic disorders and cancer. Its FDA-approved products include TAVALISSE (fostamatinib), an oral SYK inhibitor for chronic ITP; REZLIDHIA (olutasidenib), for relapsed/refractory AML with IDH1 mutation; and GAVRETO (pralsetinib), for metastatic RET fusion-positive NSCLC and advanced thyroid cancer. Its pipeline includes R289, a dual IRAK1/4 inhibitor in Phase 1b for lower-risk MDS.","people":[],"products":[{"name":"TAVALISSE (fostamatinib disodium hexahydrate)","type":"service","description":"Oral SYK inhibitor approved for adult patients with chronic immune thrombocytopenia (ITP) who had insufficient response to prior treatment; available in US, Europe, UK, Japan, Korea, Canada, and Israel."},{"name":"REZLIDHIA (olutasidenib)","type":"service","description":"Oral IDH1 inhibitor approved for adult patients with relapsed or refractory AML with a susceptible IDH1 mutation; in-licensed from Forma Therapeutics (now Novo Nordisk)."},{"name":"GAVRETO (pralsetinib)","type":"service","description":"Once-daily oral RET kinase inhibitor approved for metastatic RET fusion-positive NSCLC and advanced/metastatic RET fusion-positive thyroid cancer; acquired from Blueprint Medicines Corporation."},{"name":"R289","type":"platform","description":"Dual IRAK1/4 inhibitor in open-label Phase 1b study for lower-risk myelodysplastic syndrome (MDS) relapsed, refractory, or resistant to prior therapies."}],"partnerships":[{"partner_name":"Forma Therapeutics (now Novo Nordisk)","partnership_type":"licensing","description":"License and transition services agreement granting Rigel exclusive worldwide rights to develop, manufacture, and commercialize olutasidenib (REZLIDHIA), entered July 2022.","start_date":null},{"partner_name":"Blueprint Medicines Corporation (now a Sanofi SA company)","partnership_type":"licensing","description":"Asset purchase agreement granting Rigel rights to research, develop, manufacture, and commercialize GAVRETO in the US, entered February 2024.","start_date":null},{"partner_name":"University of Texas MD Anderson Cancer Center (MDACC)","partnership_type":"strategic","description":"Strategic development collaboration to evaluate olutasidenib in other disease areas with IDH1 mutations.","start_date":null},{"partner_name":"Collaborative Network for Neuro-Oncology Clinical Trials (CONNECT)","partnership_type":"strategic","description":"Strategic development collaboration to expand evaluation of olutasidenib in IDH1-mutant disease areas.","start_date":null},{"partner_name":"Eli Lilly and Company","partnership_type":"development","description":"Partner leading clinical development of Rigel's RIPK1 inhibitor program.","start_date":null}],"affiliations":[],"origin":{"leaf":"56610c9be12e1fd95cc91d4cd823ebf4a2bd18e0cc0e08b3f5201e1f29e706b4","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"795eeff29d3f54beec31b7d678e633aee6854514d6f3a88e020f7d05b663625c","parent":"356ac783a94426d43b181ddf5288ff0330e262559ffd3f15dc84d5197ff6e7fc","source":"0001034842-26-000015","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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