{"schema":"rootz.ai/sec-company/v1","layer":1,"cik":"0001544227","name":"Tempest Therapeutics, Inc.","summary":"Tempest Therapeutics is a clinical-stage biotechnology company advancing a diversified portfolio of CAR-T cell therapy and small molecule product candidates. Its pipeline includes TPST-2003, an autologous CD19/BCMA dual-targeting CAR-T therapy for relapsed/refractory multiple myeloma; amezalpat (TPST-1120), an oral PPARα antagonist that is Phase 3-ready for first-line hepatocellular carcinoma; and TPST-1495, a dual EP2/EP4 PGE2 antagonist entering Phase 2 for familial adenomatous polyposis. The company also holds allogeneic and in vivo CAR-T programs targeting CD70 and BCMA/CD19.","people":[],"products":[{"name":"TPST-2003","type":"platform","description":"Autologous dual-targeting CD19/BCMA CAR-T therapy in clinical development for relapsed or refractory multiple myeloma."},{"name":"Amezalpat (TPST-1120)","type":"platform","description":"Oral, selective PPARα antagonist; Phase 3-ready for first-line unresectable or metastatic hepatocellular carcinoma."},{"name":"TPST-1495","type":"platform","description":"Novel dual EP2/EP4 PGE2 receptor antagonist entering NCI-funded Phase 2 study in familial adenomatous polyposis."},{"name":"TPST-2206","type":"platform","description":"Autologous dual-targeting CD70/CD70 CAR-T therapy targeting solid tumors."},{"name":"TPST-3003","type":"platform","description":"Allogeneic BCMA/CD19 dual-targeting CAR-T therapy with TRAC locus gene edit."},{"name":"TPST-3206","type":"platform","description":"Allogeneic CD70/CD70 dual-targeting CAR-T therapy with TRAC locus gene edit."},{"name":"TPST-4003","type":"platform","description":"In vivo dual-targeting CAR-T program designed as a scalable extension of TPST-2003 biology."}],"partnerships":[{"partner_name":"Novatim Immune Therapeutics","partnership_type":"licensing","description":"Exclusive license to patents for TPST-2003 and TPST-2206 programs; funds TPST-2003 clinical development in China.","start_date":null},{"partner_name":"Factor Bioscience Inc.","partnership_type":"licensing","description":"Exclusive license to patents for TPST-3003 and TPST-3206 allogeneic programs; Joint Steering Committee established.","start_date":null},{"partner_name":"National Cancer Institute (NCI)","partnership_type":"development","description":"NCI funding and CP-CTNet conducting the Phase 2 clinical trial of TPST-1495 in FAP patients.","start_date":null}],"affiliations":[],"origin":{"leaf":"cf63d9865f764b1ed15c872615bb0a14021dc01520f41580b90b49a72afea01e","formula":"v2: sha256( sha256(content) || parent || source_accession )","content_sha256":"46a8c92c7bbb99e1d878f58e63e0038e847d666aad6c0a4a7ad6dbf337d86b86","parent":"b37841cbd37b9490a53ffe123a8d32898820e387404d0c098f62246c013c0a22","source":"0001193125-26-130490","chain":"sec.gov/EDGAR (retrieved over TLS, accession recorded) > origin.rootz.global extraction > this response","registry":"origin.rootz.global","verify":"Recompute it: sha256(sha256(<this response body minus the origin block>) || parent || source_accession). 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